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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Quercetin, Cisplatin
Phytochemical Name Quercetin (PubChem CID: 5280343 )
Anticancer drug Name Cisplatin (PubChem CID: 5702198 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 476
Ref_1
Pair Name Quercetin, Cisplatin
Disease Info [ICD-11: 2C73] Ovarian cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Cleavage CASP3 hsa836
Up-regulation Cleavage CASP7 hsa840
Up-regulation Cleavage CASP9 hsa842
Down-regulation Phosphorylation MTOR hsa2475
Up-regulation Cleavage PARP1 hsa142
Down-regulation Phosphorylation STAT3 hsa6774
Down-regulation Expression Trx1 KEGG ID N.A.
Down-regulation Expression Trx2 KEGG ID N.A.
Down-regulation Expression TrxR KEGG ID N.A.
In Vitro Model SK-OV-3 Ovarian serous cystadenocarcinoma Homo sapiens (Human) CVCL_0532
SKOV-3/CDDP Cisplatin-resistant ovarian serous cystadenocarcinoma Homo sapiens (Human) N.A.
Result This study provides further new data for the mechanism by which the QU pre-treatment re-sensitizes SKOV-3/CDDP cells to cisplatin.
03. Reference
No. Title Href
1 Potentiation of Cisplatin Cytotoxicity in Resistant Ovarian Cancer SKOV3/Cisplatin Cells by Quercetin Pre-Treatment. Int J Mol Sci. 2023;24(13):10960. Published 2023 Jun 30. doi:10.3390/ijms241310960 Click
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